Cell cycle non-specific drugs are most effective when administered how?

Cell cycle non-specific drugs are designed to target cancer cells regardless of which phase of the cell cycle they are in. These drugs can act on both dividing and non-dividing cells, meaning their therapeutic effect is not limited to a particular time when the cells are actively proliferating.

Administering such drugs as a bolus allows for a concentrated dose to be delivered quickly to the body, potentially overwhelming the cancer cells and maximizing their exposure to the drug. A bolus administration can lead to a higher peak concentration of the drug in the bloodstream, which is crucial for effectively eradicating cancer cells.

In contrast, continuous infusion or low, frequent doses might not achieve the high peak concentrations that are often necessary to ensure that the drugs exert their maximum effect on the tumor. While divided doses can help maintain drug levels, cell cycle non-specific drugs benefit from a rapid and substantial presence in the system to effectively reduce tumor burden.