Which of the following chemotherapy agents are classified as hormonal agents?

Hormonal agents in chemotherapy are medications that specifically target and modulate hormonal pathways to treat certain types of cancer, particularly those that are hormone-sensitive such as some breast and prostate cancers. Corticosteroids, which are classified as hormonal agents, serve multiple therapeutic roles in oncology. They can be used to reduce inflammation, manage symptoms like pain, and act as anti-nausea agents. In some cases, they can also exert direct antitumor effects and are involved in managing the side effects of other chemotherapy treatments.

The other categories listed do not fall under the classification of hormonal agents. Taxanes, for instance, are a class of chemotherapy drugs that work primarily by interfering with the mitosis of cancer cells. Alkylating agents damage DNA to prevent cancer cells from dividing, while antimetabolites disrupt normal metabolic processes in cells, specifically targeting rapidly dividing cells. None of these mechanisms involve the modulation of hormonal pathways. Hence, corticosteroids are distinctly recognized as hormonal agents due to their specific physiological functions related to hormone regulation and their utility in cancer therapy.